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Further studies revealed that GLC increases melanin production in melanocytes by three pathways, 1) activating activator protein-1 (AP-1) and CRE promoter to activate p42/44 MAPK signaling, 2) activating cAMP signaling, and 3) decreasing GSK3 phosphorylation while inducing CREB phosphorylation (Lee et al., 2005)

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While this kind of study is important for quickly raising awareness on emerging safety signals from novel pharmacotherapies it advances a safety concern that we already know and that has been settled by other studies using a more apt design for investigating such a research question, explained De Giorgi

Formulation Stability and Laboratory Handling: Analysis of formulation integrity, storage conditions, handling procedures, and stability within research environments