tirzepatide once weekly for the treatment of obesity journal club In an earlier analysis SURMOUNT-1 trial, (a dual glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1] receptor agonist) was shown to provide substantial and sustained reductions in body weight Participants with obesity achieved weight

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In the first trial involving patients who did not use continuous positive airway pressure (CPAP) therapy, tirzepatide resulted in an average reduction of 25.3 events per hour in AHI after 52 weeks of treatment, compared to only 5.3 fewer events with a placebo

Knowing this timeline helps patients push through the difficult first month understanding that relief is predictable and coming

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Use of CD19-targeted immune modulation to eradicate AAV-neutralizing antibodies