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Early oocytes exhibit limited Complex I activity, which keeps ROS levels low [40], but as oocytes mature, antioxidant defenses decline, allowing ROS accumulation [37]

The article frames that as a decision point where a provider weighs escalation, switching medication, combination therapy, or investigating barriers such as poor adherence, diet quality or unaddressed metabolic conditions

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You're not just thinking about whether you remembered to pack it you're thinking about whether it's still viable, whether the injection timing still works across time zones, and whether the person at airport security is going to make the next five minutes interesting