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In subsequent studies: PIONEER-6 and ELIXA the primary endpoints (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, hospitalization for unstable angina) were not met in the GLP-1 RAs group, but a significant decrease in glycated hemoglobin was observed
studies show cholesterol gains persist even when weight remains stable, indicating direct pharmacological action on lipid metabolism independent of body composition changes
Serious but rare adverse effects associated with injectable GLP-1 receptor agonists include acute pancreatitis, gallbladder disease (cholecystitis and cholelithiasis), and potential thyroid effects
Even a short walk after meals can make a big difference in reducing sulfur burps
Drawbacks of the 1ml approach Accuracy is the main concern