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[9] [10] This extended elimination period provides a built-in "taper" effect, allowing the body to adjust as drug concentrations decline progressively rather than precipitously

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Liley realiz la primera transfusin intraperitoneal fetal en 1963 (1) , seguida del trabajo de Graham Liggins (2) , quien con su slido estudio permiti entrar de manera pionera a la Obstetricia en el campo de la medicina basada en la evidencia - MBE, logr demostrar la induccin de la madurez fetal mediante el uso de esteroides administrados a la madre