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In cases of overdose of alpha lipoic acid, some patients have developed lactic acidosis, hemodynamic instability, rhabdomyolysis, renal dysfunction, and multiorgan failure, but symptoms of neurologic, cardiac and renal dysfunction generally predominate and liver injury may be the result of shock and ischemia
8,9 Furthermore, smokers inhale 1 g of iron per 25 cigarettes and the smoke itself releases iron from ferritin, giving the lung surface fluid ample iron to generate the toxic hydroxyl radical through the Haber-Weiss and Fenton reactions
USA 101 , 66696674 (2004)
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15 however, when there is a disproportionately high amount of ROS, it induces oxidative tissue damage