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The trial met the major efficacy outcome measures of objective response rate and duration of response in both treatment groups, according to Pfizers announcement

J Neurochem 133:700707 Emamzadeh FN, Surguchov A (2018) Parkinsons Disease: Biomarkers, Treatment, and Risk Factors

When considering the combination of these medications, several factors should be taken into account: Overlapping side effects Both medications can cause gastrointestinal symptoms, which may be additive when used together

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Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, et al

Nature 421 : 7075