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Generalised burning sensations may relate to diabetic neuropathy, allergic reactions, or coincidental dermatological conditions rather than Ozempic itself

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However, the challenge with current TRPV1 antagonists lies in their associated adverse effects, such as hyperthermia 24,25,26,27,28,29,30,31 and hypothermia 32,33,34 , caused by failures in thermoregulation

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Note table 3 does not include the 3.0mg and 4.5mg of dulaglutide, which lower A1c by 1.6% and 1.8% respectively (285)

Gastrointestinal effects : GLP-1 receptor agonists as a class are well known to cause nausea, vomiting, and delayed gastric emptying