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Perimenopause is the time leading up to menopause when estrogen and progesterone levels start to fluctuate

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Rapid tumor necrosis factor -induced exocytosis of glutamate receptor 2-lacking AMPA receptors to extrasynaptic plasma membrane potentiates excitotoxicity

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and (3) tune dose, timing, and delivery (mitochondria-, ER-, or plasma-membrane-targeted) to preserve physiological H 2 O 2 signaling while attenuating pathological microdomains