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PPP-produced NADPH is considered to be crucial in the defence against oxidative stress, which is often induced by exogenous sources or disrupted mitochondrial activity 26

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In the LPS-induced acutelung injury mouse model, treatment of GHK-Cu also significantly suppressed TNF- and IL-6 expression with a significant decrease of both NF-B p65 and p38 MAPK signaling, suggesting that GHK-Cu is useful for the development of novel anti-inflammatory therapies [22]

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[DOI] [PubMed] [Google Scholar] Wallace TC