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The ability of curcumin to down-regulate the expression of fibronectin, one of the ECM proteins, which is overexpressed in leiomyoma as compared to normal myometrium, has also been documented (Supriono et al., 2018) suggest the possible mechanism of curcumin in producing anti-uterine fibroid activity via reducing the ECM production, thus further study investigating the effects of curcumin on various ECM-related receptors and proteins in leiomyoma cells may be conducted

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