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Prospective cohort studies on the association have been inconsistent: a few studies have linked higher choline intakes to increased risks of atrial fibrillation (122) and cardiovascular disease-related mortality (43, 44), while several other prospective studies have found no association between choline intake and cardiovascular disease endpoints (41, 45-48)

These findings suggest that melatonins antioxidative effects may be more therapeutically relevant early during the disease

10.1016/j.jneumeth.2024.110256 100 MaoL.LongL.QinQ.HuangQ.HuangQ.YuY.et al (2025)

The good news is that most causes are not dangerous and can be managed with simple steps