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NAD+ is a coenzyme found in every living cell that's essential for energy metabolism, DNA repair, and cellular signaling

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In patients with MDD, elevated circulating cell-free mtDNA (ccf-mtDNA) may reflect stress-induced mitochondrial genome release [27,28,29], and both mtDNA and ccf-mtDNA negatively correlate with cognitive function [30, 31]

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80 These protein complexes play an important role in fibroblast activation in the kidney, and their inhibition reduces or prevents the progression of CKD