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b , Gene ontology analysis of significantly downregulated genes in SLC25A39/40 double knockout Jurkat cells

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Conclusion The multifaceted nature of age-associated cognitive decline calls for complex approaches that address all key factors involved in the development of neurodegenerative disorders such as oxidative stress, neuroinflammation, disrupted bioavailability of copper, impaired circulation, and altered gene expression

At the bioactive ingredient level, salicin B, puerarin, and astragaloside A demonstrated the strongest associations with ferroptosis-related targets (103)