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A stratified Cox proportional hazards model was used, with treatment as a fixed effect and trial-level cardiovascular risk as the stratification factor, to estimate hazard ratios (HRs) and confidence intervals (CIs) when comparing tirzepatide to the control

The cyclic structure and the D-residue introduce their own verification questions: mass spectrometry confirms composition but cannot distinguish a D-phenylalanine from an L, since the two are isobaric, and cyclization changes mass by only the loss of water relative to the linear precursor

Acta Neuropathol (2012) 123(3):349367

Lionetti, E., et al

Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease

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