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There are currently around 54 million patients with a diagnosis of dementia worldwide with incidence rates predicted to triple internationally to 152 million people by 2050 and will cost health services $2 trillion a year by 2030 as per the World Alzheimer Report 2018 [3]

If they cannot get in, they cannot be burned for energy

Liraglutide Versus Sitagliptin for Patients With Type 2 Diabetes Who did Not Have Adequate Glycaemic Control With Metformin: A 26-Week, Randomised, Parallel-Group, Open-Label Trial

Among patients with chronic hepatitis, 30% progress to cirrhosis, 46 so that the incidence of cirrhosis in patients initially infected with hepatitis C is approximately 10%

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14,38,39 Several therapies currently in clinical development target glucagon receptors in addition to incretin receptors due to the effects of glucagon on reducing food intake and increasing energy expenditure