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Bibcode:1988PNAS...85.7831S

(Defines the roles of major selenoproteins, including glutathione peroxidases and thioredoxin reductases.) Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, Hurst R

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Inhibition of de novo palmitate synthesis by fatty acid synthase induces apoptosis in tumor cells by remodeling cell membranes, inhibiting signaling pathways, and reprogramming gene expression

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This shift may attenuate GHSR signalling and has been proposed to contribute to reduced ghrelin responsiveness, potentially impairing adaptive homeostatic responses during caloric restriction or weight loss attempts