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C-peptide administration to patients with type 1 diabetes significantly reduced urinary albumin excretion and improved renal function. Wahren et al., NEJM 2

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The effect of this synergistic treatment is ASS-dependent, and the activity of the enzymes mentioned above can be restored by transfection of ASS, eliminating the sensitivity of tumor cells to ADI-PEG20 combined with 5-FU treatment