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First attempts in this direction have been made by pioneer work of Marijan Petek with preparation of crude, partially purified concentrate from human gastric juice 2 and finalized by R

182,183 Moreover, physcion and its derivative S3, novel small-molecule PGD inhibitors which fits in a pocket of PGD near the binding site of 6-PG to inhibit PGD enzyme activity and then decrease the NADPH level, exhibit excellent anticancer effects and sensitize leukemia cells to antimalarial agent dihydroartemisinin (DHA)

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doi: 10.3171/2022.9.JNS221565 296 Risby-JonesG.MarallagJ.JagarajC