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As we age, our body's natural production of glutathione decreases, which can lead to increased oxidative stress and cellular damage
Indeed, administering GLP-1R agonists into the fourth ventricle in mice decreases food intake and body weight [21, 22], and GLP-1R knockdown in NTS neurons increases food intake [23, 23]
When the sensitive CO23 strain was treated with MCFG or FLC, a general decrease in the GSH/GSSG ratio was observed, indicating that both these drugs induced an oxidative stress
Data were acquired in data-independent acquisition PASEF mode with the following settings: m / z range from 100 m / z to 1,700 m / z , ion mobility range from 1/K 0 = 1.300.85 V s cm 2 using equal ion accumulation and ramp times in the dual TIMS analyser of 100 ms each
YangKZhangXJCaoLJLiuXHLiuZHWangXQet alToll-like receptor 4 mediates inflammatory cytokine secretion in smooth muscle cells induced by oxidized low-density lipoprotein