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Tolerance: Over time, you may need more kratom to feel the same effect, which compounds other risks on this list

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Accordingly, selective targeting of GSH-dependent nodes (such as cysteine transport, mitochondrial GSH import, compartmentalized GSH degradation, or NADPH-dependent regeneration) may offer greater specificity and efficacy than indiscriminate redox perturbation

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[DOI] [PMC free article] [PubMed] [Google Scholar] Giannoulis MG, Sonksen PH, Umpleby M, Breen L, Pentecost C, Whyte M, et al