When frataxin was absent, Fe-S synthesis was blocked, which not only interfered with the normal ETC but also forced cells to compensate for these effects by taking up additional iron, leading to iron overload and oxidative stress and triggering mitophagy [187]
The rise of GLP-1 receptor agonists such as Ozempic, Wegovy, Zepbound, and Mounjaro now accounts for a global pharmaceutical market share in the tens of billions of dollars annually estimated in 2024 to be $53 billion and expected to grow to $150 billion by 2030
Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, et al
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