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Symptoms include: The pale yellow color of the skin Red, painful tongue Pins and needles, numbness, or other strange feelings in the hands, legs, or feet Vision disturbances Having trouble walking and keeping your balance Loss of memory and sadness Differences in mood, thoughts, feelings, and behavior are easily observed Confused and unable to think

In this scenario, a deep understanding of c-MET inhibitors toxicity profiles and the potential for overlapping toxicities in combination strategies is crucial

Ono M, Isono K, Sakata Y, Taji T

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers

(2017) as well as chemotherapeutic resistance (Iwasawa et al., 2011