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The glucagon receptor antagonists (GRA) L-168049 and REMD2.59 were from Tocris Bioscience (Bristol, UK) and REMD Biotherapeutics Inc (Camarillo, CA, USA), respectively

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However, the receptor's manipulation is fraught with complexity, as evidenced by the paradoxical contraindication of beta-blockade in cocaine toxicity, where unopposed alpha-agonism poses a grave risk