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Arteriosclerosis, thrombosis, and vascular biology

Pharmacokinetic work by Urva and colleagues (Lancet, 2022) reported a long elimination half-life in the region of six days, consistent with the albumin-binding design

GIPR, unlike the GLP1R, is extensively expressed in the ventricular myocardium of both rodents and humans

At 9mg weekly: Nausea: 38.1% Diarrhea: 34.7% Constipation: 21.8% Vomiting: approximately 15-20% At 12mg weekly: Nausea: 43.2% Diarrhea: 33.1% Constipation: 25.0% Vomiting: approximately 18-22% These numbers look concerning, but context matters

Fabi, & Dr

Bu T, Sun Z, Pan Y et al (2024) Glucagon-like peptide-1: new regulator in lipid metabolism