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Clinical study characteristics All included studies were categorized based on key characteristics, including study duration, start year, geographical location and the number of clinical centers involved

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Methionine can act as a precursor to N-acetyl cysteine, which is considered to be the rate limiting step for making glutathione.3 Glutathione is composed of 3 amino acids: glycine, cysteine, and glutamine

Downregulated ERMN might be one of the potential mechanisms of myelination deficits and hippocampus-dependent spatial learning and memory dysfunction in young animals and children

The MHRA and EMA continuously monitor the safety of these medications, and patients are encouraged to report suspected side effects via the MHRA Yellow Card scheme