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TB-500 has a substantially longer plasma half-life, approximately two to three hours after subcutaneous or intramuscular administration in rats, followed by tissue redistribution

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According to the Merck Manuals, bioavailability is the extent and rate within which an active drug enters systemic circulation after passing through the first-pass metabolism sites, namely, the intestinal wall and liver

Experiments or tissue collection were initiated starting from the third week after viral injection

The headline finding: spironolactone was well tolerated