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Hormones level assessment For mouse model characterization, blood samples were collected at 1215 weeks of age, and serum levels of GH, PRL, and TSH were measured using the MILLIPLEX Mouse Pituitary Magnetic Bead Panel (Millipore Sigma, Burlington, MA, USA) according to the manufacturers instructions

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Environmental Stress: Pollutants in the air, chemicals in household products, and UV radiation from the sun all create free radicals