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25,26 Carriage of the 3R and insertion alleles for these variants results, respectively, in higher translation efficiency and negatively altered mRNA stability

To further elucidate the therapeutic mechanisms underlying D-CuPs multivalent interactions, comprehensive proteomic analysis revealed two pivotal transcriptional regulators, the tumor suppressor protein p53 and histone deacetylase 7 (HDAC7) to be potential mechanistic targets

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Oxidation Chemistry of Catecholamines and Neuronal Degeneration: An Update