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Conversely, mice possess highly active UOX, which rapidly oxidizes and degrades uric acid into highly water-soluble allantoin for excretion, thereby maintaining extremely low serum uric acid levels

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It is therefore unsurprising that pharmacological solutionsparticularly GLP-1 receptor agonistshave seen such rapid adoption

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doi: 10.1016/s0074-7742(02)50072-6, 61

You get thickened up and a lot of thats cortisol