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This difference is likely to be related to the more tightly packed ECD interface of RAMP2 and CTR, driven by the interactions with P37 Cagri , and the preferential CTR engagement by Cagri via a bypass conformation, as discussed below in the context of CTR complexes

Given differences among trials regarding antioxidant intervention type, altitude reached, exposure duration, and sample size, clinical and methodological heterogeneity was assumed