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GLP-1 receptor activation reduces appetite, slows gastric emptying, promotes insulin secretion from pancreatic beta cells, and creates the characteristic feeling of fullness that GLP-1 agonist users report

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Similarly, PNPLA3 I148M promotes hepatosteatosis through ABHD5-dependent inhibition of PNPLA2 (75), suggesting that small molecules that target the PNPLA3 I148M/ABHD5 interaction could be potential therapeutics for FLD and diabetes