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So, additional investigation is necessary to link these potential associations to konzo pathogenesis, particularly in relation to time of disease onset, as such markers may only be present during early phases of konzo onset when inflammation or neural damage is likely highest

Additionally, although true allergies to glycine are exceedingly rare, any prior hypersensitivity reaction to glycine or to components of the formulation would contraindicate its use

Oxidative stress markers (HO-1, ROS), inflammatory markers (NF-B), mitochondrial integrity, and tight junction proteins provide sensitive indicators of sub-lethal toxicity, guiding safe biomedical translation [162, 166]

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Journal of basic and clinical physiology and pharmacology