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Some confusion may arise from studies examining the effects of water consumption on metabolic parameters

Food & Function, 9 (2), 705714

Some studies report small improvements in recovery markers (reduced muscle soreness, lower creatine kinase) after eccentric exercise, possibly due to improved blood flow or antioxidant effects rather than a metabolic mechanism

this finding is consistent with that of another study, that is, the activation of the MAPK pathway (e.g., ERK1/2 activation) is involved in ER stress, cell proliferation, cell cycle arrest, and autophagy 38

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"Nicotinamide N-methyltransferase regulates hepatocellular carcinoma metabolic plasticity." Journal of Clinical Investigation , 128(3), 973987