Retatrutide is the unimolecular triple agonist furthest in development and data from phase 2 trials suggests that this may soon become the most potent weight-lowering pharmacotherapy to be licenced
Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study of adults with obesity or overweight
This is why body-composition-focused care matters
Long-acting formulations, such as dulaglutide, liraglutide, and once-weekly exenatide, have consistently shown superior efficacy in reducing both fasting plasma glucose and HbA1c levels when compared to shorter-acting alternatives like twice-daily exenatide and lixisenatide (Htike et al
Metformin, the cornerstone of T2DM therapy, activates AMP-activated protein kinase (AMPK), which has been shown to normalize SR/ER-mitochondria interactions ( 2+ overload (Wu et al., 2019)
PubMed CrossRef Kuo T, McQueen A, Chen TC, et al