Semaglutide Both tirzepatide and semaglutide are powerful tools, but they act slightly differently: Semaglutide A GLP-1 receptor agonist Weekly injection (brand names Ozempic for diabetes, Wegovy for weight loss) Helps many patients achieve 1015% weight loss with lifestyle support Tirzepatide Dual-action: mimics GLP-1 and GIP (another metabolic hormone) Weekly injection (brand names Mounjaro and Zepbound) Some clinical trials show average weight loss of 1520% or more Because tirzepatide acts on two hormone pathways, it may have enhanced benefits for blood sugar control and weight reduction
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At the same time, human milk oligosaccharides (HMOs) act as prebiotics and selectively promote a tolerable gut microbiome rich in beneficial bacteria such as Bifidobacterium and Lactobacillus, which are essential for training the immune system and maintaining a balance between inflammatory and regulatory responses [16, 17]
JAMA Intern Med 182(5):513519
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Potential Risks and Gastrointestinal Side Effects What Does Current Research Say About GLP-1 and IBD
