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10.1038/s41586-025-08770-0 54 KumariJ.VinnakotaR.KumarJ

Regulatory note: Injectable/IV NAD+ is not FDA-approved (or approved by any major regulator) for energy, metabolic or longevity uses

Supports intracellular redox balance , a core mechanism tied to cellular stability and recovery

Metallothionein, the only known protein implicated in cellular zinc distribution, binds 7 zinc atoms via thiolated ligands

Smeal, SJ

Researchers continue to investigate whether the broad gene-regulatory actions attributed to GHK-Cu may support tissue architecture and cellular resilience through coordinated effects on collagen synthesis, antioxidant defence and extracellular matrix remodelling