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One study found lower vitamin B 12 levels in the cerebrospinal fluid of patients with Alzheimer's disease than in patients with other types of dementia, though blood levels of vitamin B 12 did not differ (65)

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In RA patients, an alteration of DNA methylome signature in PBMC and a reduction of 5-mC amounts in synovial tissues were observed, the alteration of FLS gene expression, including chitinase-3-like protein 1 (CHI3L1), caspase 1 (CASP1), STAT3, mitogen-activated protein kinase kinase kinase 5 (MAP3K5), familial Mediterranean fever (MEFV), and wnt1-inducible signaling protein 3 (WISP3), is caused by differentially methylated genes leading to the pathogenesis of RA (293)

It originates from Indonesia and today grows in warm climates worldwide