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People with injection hesitancy who still want GLP-1 benefits

with oral GLP-1, absorption depends heavily on fasting state and timing

The researchers discovered that small-molecule GLP-1 drugs significantly reduced how much dopamine, a neurotransmitter thats commonly associated with reward-motivated behaviors, was released, essentially changing the animals perception of how rewarding that food is. Gler hopes that his teams discovery can help guide future efforts in designing GLP-1 drugs that target specific parts of the brain, such as the reward center

Tolerability Issues : The adverse events with the GLP-1-based therapies are primarily gastrointestinal and include nausea, vomiting, constipation, or diarrhea [82], leading to meaningful discontinuation rates that limit real-world effectiveness

The effect of GLP-1 receptor agonists on circulating inflammatory markers in type 2 diabetes patients: A systematic review and meta-analysis

Tirzepatide affects multiple metabolic pathways, which may increase digestive sensitivity in some individuals