Retatrutide is a triple-receptor agonist peptide that targets GLP-1, GIP, and glucagon pathways, making it a compound of significant interest in metabolic research
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And that process which is beneficial to plans, members and the bottom line is uniquely driven by pharmacists with the knowledge to appropriately evaluate the class of drugs, the patients needs, and the costs involved
A single trial that evaluated GLP1RAs in patients with a history of HF and HFpEF demonstrated reduced HF hospitalizations
David Goodman, published in P&T Journal in May 2010
Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023
