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Yamamoto K, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S et al (2016) MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

Immunofluorescence examination of the spinal cord revealed that teneligliptin inhibited the immunoreactivity of glial fibrillary acidic protein, indicating that its analgesic effects are associated with the suppression of spinal astrocyte activation thereby preventing neuroinflammation [70]

We know that obesity is associated with AF progression and worse outcomes- we've discussed that previously here

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