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Searches were conducted in PubMed, Scopus, and Web of Science through November 2025, supplemented by snowball methods, focusing on studies investigating antioxidant treatments in humans exposed to hypobaric or high-altitude hypoxia

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Vital signs, ECGs, and physical exams showed no significant changes, and no cases of cancer or serious adverse events were reported over six months of follow-up [42]

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no major safety concerns were observed

Moreover, Ki67-insulin double staining revealed that PG-102 significantly maintained the proportion of proliferating -cells, supporting preservation of regenerative potential (Fig