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This is accompanied by a shift in macrophage populations, with a higher number of pro-inflammatory M1 macrophages and reduced anti-inflammatory M2 macrophages in Hunner lesions

The penta-mutant ZJ12345 was constructed successfully, and the production of GSH was 19.10 mM in fed-batch fermentation, which was 1.33-fold the production of MG1655 expressing the same gene

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