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Dose Escalation Structure Phase Weekly Dose Weeks 14 1 mg Weeks 58 2 mg Weeks 912 4 mg Maintenance (research range) 68 mg Clinical trials have evaluated doses up to 12 mg once weekly with gradual titration

Since then, few patients discontinued setmelanotide due to objections over pigment changes

However, the mechanisms underlying these effects have not been fully elucidated, with some preclinical studies revealing inconsistent results (20)

Maximin Navarro, our resident dermatologist and a Philippine Dermatological Society (PDS) fellow, here

It is important to inquire about these to make sure they are right for you

Figure 4: Glutathione conjugation with 1,2-dibromoethane causing formation of the highly reactive episulphonium ion [Figure source: Timbrell (2009) Biochemical Mechanisms of Toxicity.4 th Ed