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It is usually possible to continue with slow benzodiazepine tapering while starting on an antidepressant, although some may prefer to halt their programme for 2-3 weeks until the antidepressant has taken hold (but increasing the benzodiazepine dose should be strenuously avoided)

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The mechanisms do not appear to contradict each other, and some researchers have speculated that combining them could address both appetite and direct fat cell metabolism

However, tirzepatide has a longer track record and more extensive safety data