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Kosiborod MN, Abildstrm SZ, Borlaug BA et al (2023) Semaglutide in patients with heart failure with preserved ejection fraction and obesity

GLP-1 microdosing generally involves doses lower than those outlined in standard prescribing guidelines, which makes it an off-label use

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When paired with an individualized low-calorie, low-fat diet and a consistent exercise program, GLP-1 therapy can help improve various health markers in overweight adults including high blood pressure, diabetes, or high cholesterol reducing cardiovascular risk and improving metabolic health

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However, dietary approaches offer distinct advantages