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Some newer drugs combine GLP-1 receptor agonists with other metabolic targets or additional mechanisms to achieve more effective weight loss
10.1016/s0305-4179(03)00004-4 122 SikiricP.SeiwerthS.RucmanR.DrmicD.StupnisekM.KokotA.et al (2017)
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Even in clinical trials, people who lost weight on tirzepatide followed a calorie-deficient diet and exercised daily
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