J Inherit.Metab Dis 2007;30(5):811
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Whats the most effective way to boost NAD levels
Weight Loss Composition is One-Fourth Fat-Free Mass: A Critical Review and Critique of This Widely Cited Rule: Weight Loss Composition. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
If you develop symptoms of hyperthyroidism while taking LDN, such as heart racing, increased anxiety, restlessness, or trouble sleeping, please stop LDN and talk to the prescriber for your thyroid medication
While generally well-tolerated, some individuals may experience side effects such as: Irritation or redness at the injection site Temporary fatigue or nausea Immediate medical consultation is recommended if you experience severe side effects or allergic reactions
