Tesamorelin adds a targeted intervention
Protocol design that models tirzepatide as semaglutide plus a GIP agonist will generate misleading data
But you still need to eat in a calorie deficit for weight loss, choose nutrient-dense whole foods most of the time, get regular physical activity including both cardio and strength training, get adequate sleep since poor sleep disrupts appetite hormones, manage stress as chronic stress elevates cortisol and promotes fat storage, and address emotional or behavioral eating patterns
No randomized controlled trials have evaluated semaglutide safety in pregnant women, so precaution is the standard clinical approach
10.1152/ajprenal.00394.2015 [DOI] [PMC free article] [PubMed] [Google Scholar] 84
References: Gentinetta, S., Guida, B., Castaldo, G., & Della Pepa, G