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In eukaryotes the electrons carried by the NADH that is produced in the cytoplasm are transferred into the mitochondrion (to reduce mitochondrial NAD + ) by mitochondrial shuttles, such as the malate-aspartate shuttle

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788 One study of nearly 2 million beneficiaries of traditional Medicare living with dementia found that PCPs were the clinician type seen by the largest percentage of those beneficiaries in the study year (2019): 87.0% of beneficiaries received care from a physician, 62.9% from a nurse practitioner and 33.1% from a physician assistant